I tried both you recommendations. Issue is still unresolved.
I have two panel objects created,
panel.pane.markup.DataFrame
panel.pane.holoviews.HoloViews
When the panel object (DataFrame) is served there are no issues encountered.
Only when the Holoviews object is served, issues arise I have noticed that after being served the objects do work for a while(few seconds) before they stop.
Could you make a copy of you code or a seperate branch? Then start removing functionality while you test the problem is still there. Eventually you will end up either identifying the cause or having a minimum reproducible example that the community could take a look at.